Please note: The next issue of SPACELINE Current Awareness (List #1,026) will be sent on Friday, December 2, 2022.SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at https://taskbook.nasaprs.com/Publication/spaceline.cfm.
Please send any correspondence to Shawna Byrd, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.
Papers deriving from NASA support:
Vigil C, Daubenspeck A, Coia H, Smith J, Mauzy C.
Matrix-assisted laser desorption/ionization analysis of the brain proteome of microgravity-exposed mice from the International Space Station.
Front Space Technol. 2022 Nov 16;3:971229.
Note: ISS results. This article is part of Research Topic “Editors’ Showcase: Microgravity–2022” (https://www.frontiersin.org/research-topics/38569/editors-showcase-microgravity—2022#overview). The Research Topic also includes an article from previous Current Awareness List #1,023 https://doi.org/10.3389/frspt.2022.1032610. Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.
Journal Impact Factor: Not available for this journal
Funding: “MALDI effort was funded by the Air Force Research Laboratory, 711 Human Performance Wing, Airman Systems Directorate. Research reported in this paper was supported by the International Space Station U.S. National Laboratory under UA-2019-019 number AR-007262.”
Lalwala M, Koya B, Devane KS, Hsu FC, Yates KM, Newby NJ, Somers JT, Gayzik FS, Stitzel JD, Weaver AA.
Effects of standing, upright seated, vs. reclined seated postures on astronaut injury biomechanics for lunar landings.
Ann Biomed Eng. 2022 Nov 9.
PI: A.A. Weaver
Note: From the abstract: “Astronauts may pilot a future lunar lander in a standing or upright/reclined seated posture. This study compared kinematics and injury risk for the upright/reclined (30°; 60°) seated vs. standing postures for lunar launch/landing using human body modeling across 30 simulations.”
Journal Impact Factor: 4.219
Funding: “This study was supported by a NASA Human Research Program Student Augmentation Award to NASA Grant No. NNX16AP89G.”
Wang W, Yuan RK, Mitchell JF, Zitting KM, St Hilaire MA, Wyatt JK, Scheer F, Wright KP, Jr, Brown EN, Ronda JM, Klerman EB, Duffy JF, Dijk DJ, Czeisler CA.
Desynchronizing the sleep-wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period.
Nat Protoc. 2022 Nov 14.
PI: C.A. Czeisler
Journal Impact Factor: 17.021
Funding: “…The development of the FD protocol and NOSA program and carrying out the FD studies described here were supported by NIH Grants P01 AG09975, R01 HL080978, R01 HL52992, R21 AT02571, U01 AG12642 and T32 HL07901; by National Aeronautics and Space Administration Grants NAS9-19435 and NAG 5-3952 and NASA Cooperative Agreement NCC9-58 with the National Space Biomedical Research Institute; and by Air Force Office of Scientific Research Grants F49620-94-1-0398, F49620-95-1-0388, FA9550-06-0080 and F49620-00-1-0266.”
Kordyum EL, Artemenko OA, Hasenstein KH.
Lipid rafts and plant gravisensitivity.
Life (Basel). 2022 Nov 7;12(11):1809. Review.
PI: K.H. Hasenstein
Note: From the abstract: “The necessity to include plants as a component of a Bioregenerative Life Support System leads to investigations to optimize plant growth facilities as well as a better understanding of the plant cell membrane and its numerous activities in the signaling, transport, and sensing of gravity, drought, and other stressors.” This article is part of Special Issue “Plants and Microgravity” (https://www.mdpi.com/journal/life/special_issues/plants_microgravity). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.253
Funding: “This research was partially supported by NASA grant 80NSSC17K0344 to KHH.”
Larrey EK, Pathak R.
Radiation-induced intestinal normal tissue toxicity: Implications for altered proteome profile.
Genes (Basel). 2022 Nov 2;13(11):2006. Review.
Note: This article is part of Special Issue “Molecular Mechanisms Responsible for Radiation-Induced Toxicity of Normal Tissue” (https://www.mdpi.com/journal/genes/special_issues/Toxicity_Tissue). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 4.141
Funding: “This research was funded by the National Institute of General Medical Sciences (NIGMS), grant number P20GM109005 (R.P.) and by the National Aeronautics and Space Administration through the Established Program to Stimulate Competitive Research (NASA-EPSCoR) mechanism, under grant number 80NSSC21M0323 (R.P.).”
Xu J, Haigney MC, Levine BD, Dineen EH.
The tactical athlete: Definitions, cardiovascular assessment, and management, and “Fit for Duty” Standards.
Cardiol Clin. 2023 Feb;41(1):93-105. Review.
PI: B.D. Levine
Journal Impact Factor: 2.410
Funding: PI reports attribution to several NASA projects including Cardiovascular Standards.
Mohammed N, Cluff K, Sutton M, Villafana-Ibarra B, Loflin BE, Griffith JL, Becker R, Bhandari S, Alruwaili F, Desai J.
A flexible near-field biosensor for multisite arterial blood flow detection.
Sensors (Basel). 2022 Nov 1;22(21):8389.
Note: This article is part of Special Issue “Wearable and Unobtrusive Technologies for Healthcare Monitoring” (https://www.mdpi.com/journal/sensors/special_issues/Wearable_Unobtrusive_HealthcareMonitoring). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.847
Funding: “This work was supported in part by a grant from the National Aeronautics and Space Administration (NASA) (Grant number: NNX16AQ99A) and a National Science Foundation Graduate Research Fellowship (Grant number: #1849525).”
Spooner RK, Wilson TW.
Spectral specificity of gamma-frequency transcranial alternating current stimulation over motor cortex during sequential movements.
Cereb Cortex. 2022 Nov 11;bhac423. Online ahead of print.
Journal Impact Factor: 4.861
Funding: “NASA Nebraska Space Grant Consortium; 1539067/National Science Foundation; T32-NS105594/NH/NIH HHS/United States.”
Rubinstein L, Kiffer F, Puukila S, Lowe MG, Goo B, Luthens A, Schreurs AS, Torres SM, Steczina S, Tahimic CGT, Allen AR.
Mitochondria-targeted human catalase in the mouse longevity MCAT model mitigates head-tilt bedrest-induced neuro-inflammation in the hippocampus.
Life (Basel). 2022 Nov 9;12(11):1838.
Note: Head-tilt bedrest and hindlimb unloading study. This article and an article below (Wang et al.) in the “Other” section are part of Special Issue “Advances in Space Biology” (https://www.mdpi.com/journal/life/special_issues/_space_biology). The Special Issue also includes articles from previous Current Awareness Lists #1,002 https://doi.org/10.3390/life12050610, #1,015 https://doi.org/10.3390/life12081176, and #1,019 https://doi.org/10.3390/life12101498. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Journal Impact Factor: 3.253
Funding: “This work was partially supported by NASA post-doctoral program NPP.”
Gómez-Zará D, Das A, Pawlow B, Contractor N.
In search of diverse and connected teams: A computational approach to assemble diverse teams based on members’ social networks.
PLoS One. 2022;17(11):e0276061.
PI: N. Contractor
Journal Impact Factor: Not available for this journal
Funding: “This study was supported by the National Institute of Health (1R01GM112938-01, 1R01GM137410-01), the National Aeronautics and Space Administration (80NSSC21K0925), and the National Science Foundation (SMA-1856090) through grants awarded to NC. This study was also supported by the Directorate for Social, Behavioral and Economic Sciences (SES-2021117) and Microsoft Research (2020 Microsoft Research Dissertation Grant) through grants awarded to DG.”
Other papers of interest:
Benghin V, Shurshakov V, Osedlo V, Mitrikas V, Drobishev S, Nechaev O, Zolotarev I, Bratolubova-Tsulukidze L.
Results of long-term radiation environment monitoring by the Russian RMS system on board Zvezda module of the ISS.
Life Sci Space Res. 2022 Nov 11. Online ahead of print.
Note: ISS results.
Mariggiò MA, Ricci G.
Advances in space biology: Cell behavior in microgravity.
Appl Sci. 2022;12(22):11575.
Note: This is an Editorial for Special Issue “Advances in Space Biology: Cell Behavior in Microgravity” (https://www.mdpi.com/journal/applsci/special_issues/Space_Biology). The Special Issue also includes articles from previous Current Awareness Lists #892 https://doi.org/10.3390/app9194042 and https://doi.org/10.3390/app10062028; #905 https://doi.org/10.3390/app10124309; #906 https://doi.org/10.3390/app10134433; #926 https://doi.org/10.3390/app10228289; #931 https://doi.org/10.3390/app11010041, https://doi.org/10.3390/app11010110, https://doi.org/10.3390/app11010068, https://doi.org/10.3390/app11073122, and https://doi.org/10.3390/app12147013. This article may be obtained online without charge.
Son M, Ryu B, Je JG, Jeon YJ, Kim DY.
Ishophloroglucin A ameliorates VEGF-induced epithelial-mesenchymal transition via VEGFR2 pathway inhibition in microgravity-stimulated human retinal pigment epithelial cells.
Antioxidants (Basel). 2022 Nov 8;11(11):2212.
Note: A 3D clinostat was used in this study. This article is part of Special Issue “10th Anniversary of Antioxidants-Advances in Health Outcomes of Oxidative Stress” (https://www.mdpi.com/journal/antioxidants/special_issues/10th_anniversary_Health). Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Wang W, Di Nisio E, Licursi V, Cacci E, Lupo G, Kokaia Z, Galanti S, Degan P, D’Angelo S, Castagnola P, Tavella S, Negri R.
Simulated microgravity modulates focal adhesion gene expression in human neural stem progenitor cells.
Life (Basel). 2022 Nov 9;12(11):1827.
Note: A random positioning machine was used in this study. This article and an article above (Rubinstein et al.) in the “NASA” section are part of Special Issue “Advances in Space Biology” (https://www.mdpi.com/journal/life/special_issues/_space_biology). This article may be obtained online without charge.
Shved D, Kuznetsova P, Rozanov IA, Lebedeva SA, Vinokhodova A, Savinkina A, Shishenina K, Rey ND, Gushin V.
Effects of isolation, crowding, and different psychological countermeasures on crew behavior and performance.
Front Physiol. 2022 Nov 15;13:963301.
Note: This article is part of Research Topic “Physiology in extreme conditions: Adaptations and unexpected reactions, Volume II” (https://www.frontiersin.org/research-topics/29492/physiology-in-extreme-conditions-adaptations-and-unexpected-reactions-volume-ii#articles). The Research Topic also includes articles from previous Current Awareness List #1,000 https://doi.org/10.3389/fphys.2022.893025 and https://doi.org/10.3389/fphys.2022.882944. This article may be obtained online without charge.
Chavez T, Gerecht S.
Engineering of the microenvironment to accelerate vascular regeneration.
Trends Mol Med. 2022 Nov 9. Review. Online ahead of print.
Welch N, Singh SS, Musich R, Mansuri MS, Bellar A, Mishra S, Chelluboyina AK, Sekar J, Attaway AH, Li L, Willard B, Hornberger TA, Dasarathy S.
Shared and unique phosphoproteomics responses in skeletal muscle from exercise models and in hyperammonemic myotubes.
iScience. 2022 Nov 18;25(11):105325.
Note: This article may be obtained online without charge.
Wang H, Gao L, Chen X, Zhang C.
Study on mass transfer in the bone lacunar-canalicular system under different gravity fields.
J Bone Miner Metab. 2022 Nov 9.
Note: From the abstract: “The bone lacunar-canalicular system (LCS) is an important microstructural basis for signaling and material transport in bone tissue, guaranteeing normal physiological processes in tissues. Spaceflight astronauts and elderly osteoporosis are related to its function, so it is necessary to reveal the mass transfer laws in bone microstructure under different gravity fields to provide insight for effective clinical treatment.”
Yang YQ, Wang NL.
Effects of special natural environments and mechanisms on intraocular pressure.
Zhonghua Yan Ke Za Zhi. 2022 Nov 11;58(11):949-53. Review. Chinese.
Note: From the abstract: “This article reviews the effects of the high-altitude hypoxia environment, space microgravity environment, deep water environment, dark environment, cold environment and ambient air pollution on IOP, and discusses the mechanisms of related IOP changes.”
Trusso Sfrazzetto G, Santonocito R.
Nanomaterials for cortisol sensing.
Nanomaterials (Basel). 2022 Oct 27;12(21):3790. Review.
Note: This article is part of Special Issue “Nanomaterials for Potential Uses in Extraterrestrial Environments” (https://www.mdpi.com/journal/nanomaterials/special_issues/nano_extraterrestrial).
Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Harris AF, Lacombe J, Sanchez-Ballester NM, Victor S, Curran KAJ, Nordquist AR, Thomas B, Gu J, Veuthey JL, Soulairol I, Zenhausern F.
Decellularized spinach biomaterials support physiologically relevant mechanical cyclic strain and prompt a stretch-induced cellular response.
ACS Appl Bio Mater. 2022 Nov 11. Online ahead of print.
Hattori T, Soga K, Wakabayashi K, Hoson T.
An Arabidopsis PTH2 gene is responsible for gravity resistance supporting plant growth under different gravity conditions.
Note: This article and the article below (Lobachevska et al.) are part of Special Issue “Plants and Microgravity” (https://www.mdpi.com/journal/life/special_issues/plants_microgravity). The Research Topic also includes articles from previous Current Awareness List #1,019 https://doi.org/10.3390/life12101484. Additional articles will be forthcoming and may be found in the link to the Special Issue. This article may be obtained online without charge.
Lobachevska OV, Kyyak NY, Kordyum EL, Khorkavtsiv YD, Kern VD.
Gravi-sensitivity of mosses and their gravity-dependent ontogenetic adaptations.
Life (Basel). 2022 Nov 4;12(11).
Note: This article and the article above (Hattori et al.) are part of Special Issue “Plants and Microgravity” (https://www.mdpi.com/journal/life/special_issues/plants_microgravity). This article may be obtained online without charge.
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